EoSD was my first Normal 1cc, but IN is easier, if only because of how easy deathbombing is (so your mistakes are never punished). TD has easy patterns, but with somewhat limited resources I struggled a bit to finally get that clear. SA is the hardest for me as I never even came close to getting the clear. In UFO the main problem is Murasa, if you deal with her without significant resource loss you can just bombspam your way through the remainder of the game.
Haven't seriously played anything past Ten Desires, so can't comment beyond that.